In situ solid-state nanopore fabrication

JP Fried, JL Swett, BP Nadappuram, JA Mol… - Chemical Society …, 2021 - pubs.rsc.org
Nanopores in solid-state membranes are promising for a wide range of applications
including DNA sequencing, ultra-dilute analyte detection, protein analysis, and polymer data …

Surface coatings for solid-state nanopores

OM Eggenberger, C Ying, M Mayer - Nanoscale, 2019 - pubs.rsc.org
Since their introduction in 2001, solid-state nanopores have been increasingly exploited for
the detection and characterization of biomolecules ranging from single DNA strands to …

Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore

KB Jeong, M Ryu, JS Kim, M Kim, J Yoo… - Nature …, 2023 - nature.com
In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the
limitations of current biophysical approaches. Here, we develop a biological nanopore …

Understanding and modelling the magnitude of the change in current of nanopore sensors

W Tang, JP Fried, RD Tilley, JJ Gooding - Chemical Society Reviews, 2022 - pubs.rsc.org
Nanopores are promising sensing devices that can be used for the detection of analytes at
the single molecule level. It is of importance to understand and model the current response …

Solid-state nanopore platform integrated with machine learning for digital diagnosis of virus infection

A Arima, M Tsutsui, T Washio, Y Baba… - Analytical …, 2020 - ACS Publications
The history of viruses in human society can never be taught without the history of detection
and treatment. As an ancient example, Egyptian mummies have been found to have scars …

Electroosmotic trap against the electrophoretic force near a protein nanopore reveals peptide dynamics during capture and translocation

A Asandei, I Schiopu, M Chinappi, CH Seo… - … applied materials & …, 2016 - ACS Publications
We report on the ability to control the dynamics of a single peptide capture and passage
across a voltage-biased, α-hemolysin nanopore (α-HL), under conditions that the …

Resistive-pulse analysis of nanoparticles

L Luo, SR German, WJ Lan, DA Holden… - Annual Review of …, 2014 - annualreviews.org
The development of nanopore fabrication methods during the past decade has led to the
resurgence of resistive-pulse analysis of nanoparticles. The newly developed resistive-pulse …

Single‐Molecule Binding Assay Using Nanopores and Dimeric NP Conjugates

R Ren, M Sun, P Goel, S Cai, NA Kotov… - Advanced …, 2021 - Wiley Online Library
The ability to measure biomarkers, both specifically and selectively at the single‐molecule
level in biological fluids, has the potential to transform the diagnosis, monitoring, and …

Nanopore‐based protein sequencing using biopores: Current achievements and open challenges

A Asandei, G Di Muccio, I Schiopu, L Mereuta… - Small …, 2020 - Wiley Online Library
The synergy of life sciences discoveries, biomolecular and protein engineering advances,
and groundbreaking nanofabrication technologies, has introduced over the past years the …

Sensing the performance of artificially intelligent nanopores developed by integrating solid-state nanopores with machine learning methods

M Taniguchi, H Takei, K Tomiyasu… - The Journal of …, 2022 - ACS Publications
Solid-state nanopores with a through-hole diameter of less than a few hundred nanometers
can detect single nanoparticles owing to the ionic current flowing through the nanopore …