The epidemiology of ALS: a conspiracy of genes, environment and time
A Al-Chalabi, O Hardiman - Nature Reviews Neurology, 2013 - nature.com
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …
[HTML][HTML] Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment
RF White, L Steele, JP O'Callaghan, K Sullivan… - Cortex, 2016 - Elsevier
Abstract Veterans of Operation Desert Storm/Desert Shield− the 1991 Gulf War (GW)− are a
unique population who returned from theater with multiple health complaints and disorders …
unique population who returned from theater with multiple health complaints and disorders …
Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—a mechanistic approach
MT Baltazar, RJ Dinis-Oliveira, M de Lourdes Bastos… - Toxicology letters, 2014 - Elsevier
The etiology of most neurodegenerative disorders is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. The role of pesticide …
interaction between environmental factors and genetic predisposition. The role of pesticide …
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy
Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is
increased in association with head injury. Repetitive head injury is also associated with the …
increased in association with head injury. Repetitive head injury is also associated with the …
Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis
E D'Amico, P Factor-Litvak, RM Santella… - Free radical biology and …, 2013 - Elsevier
Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …
[HTML][HTML] Prevalence of amyotrophic lateral sclerosis-United States, 2010-2011
P Mehta, V Antao, W Kaye, M Sanchez, D Williamson… - MMWR suppl, 2014 - cdc.gov
Abstract Problem/Condition: Amyotrophic lateral sclerosis (ALS), commonly known as Lou
Gehrig's disease, is a progressive and fatal neuromuscular disease for which no cure has …
Gehrig's disease, is a progressive and fatal neuromuscular disease for which no cure has …
[HTML][HTML] The epidemiology of ALS and the role of population-based registries
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder characterized by loss of
upper and lower motor neurons, culminating in respiratory insufficiency and death after 3–5 …
upper and lower motor neurons, culminating in respiratory insufficiency and death after 3–5 …
Cyanobacteria and BMAA exposure from desert dust: a possible link to sporadic ALS among Gulf War veterans
Abstract Veterans of the 1990–1991 Gulf War have been reported to have an increased
incidence of amyotrophic lateral sclerosis (ALS) compared to personnel who were not …
incidence of amyotrophic lateral sclerosis (ALS) compared to personnel who were not …
Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models
EN Anderson, L Gochenaur, A Singh… - Human molecular …, 2018 - academic.oup.com
Traumatic brain injury (TBI) has been predicted to be a predisposing factor for amyotrophic
lateral sclerosis (ALS) and other neurological disorders. Despite the importance of TBI in …
lateral sclerosis (ALS) and other neurological disorders. Despite the importance of TBI in …
The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials
E Beghi, A Chiò, P Couratier, J Esteban… - Amyotrophic Lateral …, 2011 - Taylor & Francis
Effective treatments for amyotrophic lateral sclerosis (ALS) have remained elusive. Only
riluzole, a drug thought to affect glutamate metabolism, improves survival albeit to modest …
riluzole, a drug thought to affect glutamate metabolism, improves survival albeit to modest …