The epidemiology of ALS: a conspiracy of genes, environment and time

A Al-Chalabi, O Hardiman - Nature Reviews Neurology, 2013 - nature.com
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …

[HTML][HTML] Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment

RF White, L Steele, JP O'Callaghan, K Sullivan… - Cortex, 2016 - Elsevier
Abstract Veterans of Operation Desert Storm/Desert Shield− the 1991 Gulf War (GW)− are a
unique population who returned from theater with multiple health complaints and disorders …

Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—a mechanistic approach

MT Baltazar, RJ Dinis-Oliveira, M de Lourdes Bastos… - Toxicology letters, 2014 - Elsevier
The etiology of most neurodegenerative disorders is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. The role of pesticide …

TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy

AC McKee, BE Gavett, RA Stern… - … of Neuropathology & …, 2010 - academic.oup.com
Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is
increased in association with head injury. Repetitive head injury is also associated with the …

Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

E D'Amico, P Factor-Litvak, RM Santella… - Free radical biology and …, 2013 - Elsevier
Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

[HTML][HTML] Prevalence of amyotrophic lateral sclerosis-United States, 2010-2011

P Mehta, V Antao, W Kaye, M Sanchez, D Williamson… - MMWR suppl, 2014 - cdc.gov
Abstract Problem/Condition: Amyotrophic lateral sclerosis (ALS), commonly known as Lou
Gehrig's disease, is a progressive and fatal neuromuscular disease for which no cure has …

[HTML][HTML] The epidemiology of ALS and the role of population-based registries

E Beghi, G Logroscino, A Chiò, O Hardiman… - … et Biophysica Acta (BBA …, 2006 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder characterized by loss of
upper and lower motor neurons, culminating in respiratory insufficiency and death after 3–5 …

Cyanobacteria and BMAA exposure from desert dust: a possible link to sporadic ALS among Gulf War veterans

PA Cox, R Richer, JS Metcalf, SA Banack… - Amyotrophic Lateral …, 2009 - Taylor & Francis
Abstract Veterans of the 1990–1991 Gulf War have been reported to have an increased
incidence of amyotrophic lateral sclerosis (ALS) compared to personnel who were not …

Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models

EN Anderson, L Gochenaur, A Singh… - Human molecular …, 2018 - academic.oup.com
Traumatic brain injury (TBI) has been predicted to be a predisposing factor for amyotrophic
lateral sclerosis (ALS) and other neurological disorders. Despite the importance of TBI in …

The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials

E Beghi, A Chiò, P Couratier, J Esteban… - Amyotrophic Lateral …, 2011 - Taylor & Francis
Effective treatments for amyotrophic lateral sclerosis (ALS) have remained elusive. Only
riluzole, a drug thought to affect glutamate metabolism, improves survival albeit to modest …