Mechanisms of drug-induced tolerance in Mycobacterium tuberculosis
SN Goossens, SL Sampson… - Clinical microbiology …, 2020 - Am Soc Microbiol
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
[PDF][PDF] Critical discussion on drug efflux in Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important
goal of tuberculosis research is to shorten the treatment to reduce the burden on patients …
goal of tuberculosis research is to shorten the treatment to reduce the burden on patients …
[HTML][HTML] Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance
A Arastehfar, F Daneshnia, N Cabrera… - Nature …, 2023 - nature.com
Candida glabrata is a major fungal pathogen notable for causing recalcitrant infections,
rapid emergence of drug-resistant strains, and its ability to survive and proliferate within …
rapid emergence of drug-resistant strains, and its ability to survive and proliferate within …
Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
DJ Greenwood, MS Dos Santos, S Huang… - Science, 2019 - science.org
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the
world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of …
world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of …
[HTML][HTML] Drug-resistant tuberculosis 2020: where we stand
A Iacobino, L Fattorini, F Giannoni - Applied Sciences, 2020 - mdpi.com
Featured Application This comprehensive overview of drug-resistant tuberculosis will be
useful for researchers to expand their knowledge beyond mechanisms other than …
useful for researchers to expand their knowledge beyond mechanisms other than …
[HTML][HTML] Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis
NC Poulton, JM Rock - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …
Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance
The emergence of drug resistance continues to afflict TB control where drug resistant strains
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …
Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance
Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis, was the leading cause of mortality worldwide in 2019 due to a single infectious …
tuberculosis, was the leading cause of mortality worldwide in 2019 due to a single infectious …
[HTML][HTML] Challenging the drug-likeness dogma for new drug discovery in tuberculosis
D Machado, M Girardini, M Viveiros… - Frontiers in …, 2018 - frontiersin.org
The emergence of multi-and extensively drug resistant tuberculosis worldwide poses a great
threat to human health and highlight the need to discover and develop new, effective and …
threat to human health and highlight the need to discover and develop new, effective and …
Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia
Mycobacterium tuberculosis (Mtb) infection is difficult to treat because Mtb spends the
majority of its life cycle in a nonreplicating (NR) state. Since NR Mtb is highly tolerant to …
majority of its life cycle in a nonreplicating (NR) state. Since NR Mtb is highly tolerant to …