Mechanisms of drug-induced tolerance in Mycobacterium tuberculosis

SN Goossens, SL Sampson… - Clinical microbiology …, 2020 - Am Soc Microbiol
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

[PDF][PDF] Critical discussion on drug efflux in Mycobacterium tuberculosis

S Remm, JC Earp, T Dick, V Dartois… - FEMS microbiology …, 2022 - academic.oup.com
Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important
goal of tuberculosis research is to shorten the treatment to reduce the burden on patients …

[HTML][HTML] Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance

A Arastehfar, F Daneshnia, N Cabrera… - Nature …, 2023 - nature.com
Candida glabrata is a major fungal pathogen notable for causing recalcitrant infections,
rapid emergence of drug-resistant strains, and its ability to survive and proliferate within …

Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages

DJ Greenwood, MS Dos Santos, S Huang… - Science, 2019 - science.org
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the
world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of …

[HTML][HTML] Drug-resistant tuberculosis 2020: where we stand

A Iacobino, L Fattorini, F Giannoni - Applied Sciences, 2020 - mdpi.com
Featured Application This comprehensive overview of drug-resistant tuberculosis will be
useful for researchers to expand their knowledge beyond mechanisms other than …

[HTML][HTML] Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

NC Poulton, JM Rock - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance

S Perveen, D Kumari, K Singh, R Sharma - European Journal of Medicinal …, 2022 - Elsevier
The emergence of drug resistance continues to afflict TB control where drug resistant strains
have become a global health concern. Contrary to drug-sensitive TB, the treatment of …

Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance

M Laws, P Jin, KM Rahman - Trends in microbiology, 2022 - cell.com
Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis, was the leading cause of mortality worldwide in 2019 due to a single infectious …

[HTML][HTML] Challenging the drug-likeness dogma for new drug discovery in tuberculosis

D Machado, M Girardini, M Viveiros… - Frontiers in …, 2018 - frontiersin.org
The emergence of multi-and extensively drug resistant tuberculosis worldwide poses a great
threat to human health and highlight the need to discover and develop new, effective and …

Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia

J Lim, JJ Lee, SK Lee, S Kim… - Proceedings of the …, 2021 - National Acad Sciences
Mycobacterium tuberculosis (Mtb) infection is difficult to treat because Mtb spends the
majority of its life cycle in a nonreplicating (NR) state. Since NR Mtb is highly tolerant to …