Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

This review discusses a set of instrumental and computational methods that are used to
characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been …

How do molecules aggregate in solution, and how do these aggregates consolidate
themselves in crystals? What is the relationship between the structure of a molecule and the …

The design of pharmaceutical cocrystals has initiated widespread debate on the
classification of cocrystals. Current attempts to classify multicomponent crystals suffer from …

It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening
model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be …

The acid··· amide dimer heterosynthon in cocrystals of aromatic acids and primary amides is
identified by marker peaks in the IR spectra that are characteristic of individual N–H··· O and …

The phenomenon of cocrystallization, which encompasses the art of making multicomponent
organic solids such as cocrystals, solid solutions, eutectics, etc. for novel applications, has …

Sildenafil is a drug used to treat erectile dysfunction and pulmonary arterial hypertension.
Because of poor aqueous solubility of the drug, the citrate salt, with improved solubility and …

A virtual cocrystal screening method based on calculated gas phase molecular electrostatic
potential surfaces (MEPS) of the individual components has been validated using …

Engineered cocrystals offer an alternative solid drug form with tailored physicochemical
properties. Interestingly, although cocrystals provide many new possibilities, they also …