Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The
mechanism of their action in B cells of the pancreas has been intensively investigated and …

This study was initiated to develop an animal model of type 2 diabetes in a non-obese,
outbred rat strain that replicates the natural history and metabolic characteristics of the …

Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic
disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present …

This review is focused on two topics related to glucose in vertebrates. In a first section
devoted to glucose homeostasis we describe how glucose levels fluctuate and are regulated …

Animal models have enormously contributed to the study of diabetes mellitus, a metabolic
disease with abnormal glucose homeostasis, due to some defect in the secretion or the …

The leaves of the white mulberry tree (Morus alba L.) are used worldwide in traditional
medicine as anti-diabetics. Various constituents of mulberry leaves, such as iminosugars (ie …

Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

Due to the high prevalence of diabetes worldwide, extensive research is still being
performed to develop new antidiabetic agents and determine their mechanisms of action …