Oxygen supply to encapsulated therapeutic cells
CK Colton - Advanced drug delivery reviews, 2014 - Elsevier
Therapeutic cells encapsulated in immunobarrier devices have promise for treatment of a
variety of human diseases without immunosuppression. The absence of sufficient oxygen …
variety of human diseases without immunosuppression. The absence of sufficient oxygen …
The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake
For humans and animal models alike there is general agreement that the central nervous
system processing of gastrointestinal (GI) signals arising from ingested food provides the …
system processing of gastrointestinal (GI) signals arising from ingested food provides the …
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 …
The effects of peripheral glucagon like peptide-1 receptor (GLP-1R) stimulation on feeding,
gastric emptying, and energetic responses involve vagal transmission and central nervous …
gastric emptying, and energetic responses involve vagal transmission and central nervous …
The TheraCyte™ device protects against islet allograft rejection in immunized hosts
M Kumagai-Braesch, S Jacobson, H Mori… - Cell …, 2013 - journals.sagepub.com
Clinically, many candidates for islet transplantation are already immunized, which increases
their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device …
their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device …
Targeting β-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins
M Salehi, BA Aulinger, DA D'Alessio - Endocrine reviews, 2008 - academic.oup.com
Progressive insulin secretory defects, due to either functional abnormalities of the pancreatic
β-cells or a reduction in β-cell mass, are the cornerstone of type 2 diabetes. Incretin-based …
β-cells or a reduction in β-cell mass, are the cornerstone of type 2 diabetes. Incretin-based …
Activation of glucagon-like peptide-1 receptor promotes neuroprotection in experimental autoimmune encephalomyelitis by reducing neuroinflammatory responses
CH Lee, SJ Jeon, KS Cho, E Moon, A Sapkota… - Molecular …, 2018 - Springer
The signaling axis of glucagon-like peptide-1 (GLP-1)/GLP-1 receptor (GLP-1R) has been
an important component in overcoming diabetes, and recent reports have uncovered novel …
an important component in overcoming diabetes, and recent reports have uncovered novel …
Protection of rat pancreatic islet function and viability by coculture with rat bone marrow-derived mesenchymal stem cells
The maintenance of viable and functional islets is critical in successful pancreatic islet
transplantation from cadaveric sources. During the isolation procedure, islets are exposed to …
transplantation from cadaveric sources. During the isolation procedure, islets are exposed to …
Effect of co-culture of mesenchymal stem/stromal cells with pancreatic islets on viability and function outcomes: a systematic review and meta-analysis
BM de Souza, AP Boucas, FS Oliveira, KP Reis… - Islets, 2017 - Taylor & Francis
The maintenance of viable and functional pancreatic islets is crucial for successful islet
transplantation from brain-dead donors. To overcome islet quality loss during culture, some …
transplantation from brain-dead donors. To overcome islet quality loss during culture, some …
Preimplantation of an immunoprotective device can lower the curative dose of islets to that of free islet transplantation—Studies in a rodent model
AK Sörenby, M Kumagai-Braesch, A Sharma… - …, 2008 - journals.lww.com
Islet graft survival inside macroencapsulation devices is suboptimal. We hypothesized that
induction of neovascularization by preimplantation of devices would improve the …
induction of neovascularization by preimplantation of devices would improve the …
Liraglutide, a long‐acting human glucagon‐like peptide 1 analogue, improves human islet survival in culture
C Toso, M McCall, J Emamaullee… - Transplant …, 2010 - Wiley Online Library
The culture of human islets is associated with approximately 10–20% islet loss, occasionally
preventing transplantation. Preconditioning of the islets to improve postculture yields would …
preventing transplantation. Preconditioning of the islets to improve postculture yields would …