HIV integrase is a rational target for treating HIV infection and preventing AIDS. It took
approximately 12 years to develop clinically usable inhibitors of integrase, and Phase I …

Lichens, symbiontic organisms of fungi and algae, synthesize numerous metabolites, the"
lichen substances," which comprise aliphatic, cycloaliphatic, aromatic, and terpenic …

Biological activity of material whether known in folk medicine or observed in planned
screening program has been the starting point in the drug research. The general pattern is …

Lichen metabolites exert a wide variety of biological actions including antibiotic,
antimycobacterial, antiviral, antiinflammatory, analgesic, antipyretic, antiproliferative and …

Lichen-forming fungi are unique organisms, producing biologically active metabolites with a
great variety of effects, including antibiotic, antimycobacterial, antiviral, anti-inflammatory …

Lichens are symbiotic associations between fungi and a photosynthetic alga and/or
cyanobacteria. Lichenized fungi have been found to produce a wide array of secondary …

Eight lichens were extracted successively with n-hexane, diethyl ether and methanol using a
Soxhlet process. The cytotoxic activity of the 24 lichen extracts was evaluated in vitro using …

Context: Lichens are composite organisms consisting of a symbiotic association of a fungus
(the mycobiont) with a photosynthetic partner (the phytobiont), usually either a green alga or …

Covering: 2001 to 2007 Lichens are composite and symbiotic organisms. Biologically, they
often have been interpreted as one organism (fungi and algae associated within a common …

HIV-1 integrase is an attractive target for anti-retroviral chemotherapy, but to date no
clinically useful inhibitors have been developed. We have screened diverse marine natural …