Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

The response to exogenous pathogens leads to activation of innate immunity through the
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern …

Intrarenal B cells in human renal allografts indicate transplant recipients with a poor
prognosis, but how these cells contribute to rejection is unclear. Here we show using single …

Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease
characterized by destabilization of podocyte foot processes. We report that transgenic …

Research over the past few years has provided fascinating results indicating that biglycan,
besides being a ubiquitous structural component of the extracellular matrix (ECM), may act …

Graft inflammation impairs the induction of solid organ transplant tolerance and enhances
acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced …

Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs)
are families of pattern recognition receptors that, together with inflammasomes, sense and …

Acute kidney injury (AKI) is an important health problem, affecting 13.3 million
individuals/year. It is associated with increased mortality, mainly in low-and middle-income …

Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood
supply returns to tissue after a period of ischemia and is associated with trauma, stroke …