Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

The aim of this review was to determine the effect of psilocybin on depressive symptoms in
patients diagnosed with life-threatening illnesses or major depressive disorder. Systematic …

A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Therapeutic claims about many psychedelic drugs have not been evaluated in any studies
of even modest rigor. The science of psychedelic drugs is strengthening however, making it …

The growing interest in the rapid and sustained antidepressant effects of the dissociative
anesthetic ketamine and classic psychedelics, such as psilocybin, is remarkable. However …

A variety of classic psychedelics and MDMA have been shown to enhance fear extinction in
rodent models. This has translational significance because a standard treatment for post …

Psychedelic compounds, including psilocybin, LSD, DMT, and 5-MeO-DMT all of which are
serotonin (5-HT) 2A receptor agonists are being investigated as potential treatments. This …

Classical serotonergic psychedelics such as lysergic acid diethylamide or the naturally
occurring compounds psilocybin and mescaline produce profound changes in mood …

Clinical trials of psychedelic compounds like psilocybin, LSD and DMT have forced a
reconsideration of how non-drug factors, like participant expectations, are measured and …

Background Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in
major depressive disorder (MDD). However, the long-term effects of PT have never been …