Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects

CQ Chu, L Yu, G Qi, YS Mi, WQ Wu, Y Lee… - Neuroscience & …, 2022 - Elsevier
Alzheimer's disease (AD) is one of the fastest growing cognitive decline-related neurological
diseases. To date, effective curative strategies have remained elusive. A growing body of …

Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism

ME Trautman, NE Richardson, DW Lamming - Aging cell, 2022 - Wiley Online Library
The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

Fibroblast growth factor 21 and the adaptive response to nutritional challenges

Ú Martínez-Garza, D Torres-Oteros… - International journal of …, 2019 - mdpi.com
The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for
obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate …

NUPR1: a critical regulator of the antioxidant system

C Huang, P Santofimia-Castaño, J Iovanna - Cancers, 2021 - mdpi.com
Simple Summary Nuclear protein 1 (NUPR1) is activated in cellular stress and is expressed
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …

A low-protein, high-carbohydrate diet exerts a neuroprotective effect on mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Parkinson's disease by …

C Chu, T Li, L Yu, Y Li, M Li, M Guo… - Journal of Agricultural …, 2023 - ACS Publications
Parkinson's disease (PD) is closely linked to lifestyle factors, particularly dietary patterns,
which have attracted interest as potential disease-modifying factors. Eating a low-protein …

Dietary patterns affect Parkinson's disease via the microbiota-gut-brain axis

CQ Chu, L Yu, W Chen, FW Tian, QX Zhai - Trends in Food Science & …, 2021 - Elsevier
Background Globally improved life expectancy has led to a significant increase in the
incidence of Parkinson's disease (PD). It is widely thought that dietary factors are crucial …

Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

MB Dommerholt, M Blankestijn… - The FEBS …, 2021 - Wiley Online Library
Dietary protein restriction has been demonstrated to improve metabolic health under various
conditions. However, the relevance of ageing and age‐related decline in metabolic flexibility …

Contraction‐regulated mTORC1 and protein synthesis: Influence of AMPK and glycogen

JR Knudsen, Z Li, KW Persson, J Li… - The Journal of …, 2020 - Wiley Online Library
Key points AMP‐activated protein kinase (AMPK)‐dependent Raptor Ser792
phosphorylation does not influence mechanistic target of rapamycin complex 1 (mTORC1) …

The gut microbiome on a periodized low-protein diet is associated with improved metabolic health

Z Li, TS Rasmussen, ML Rasmussen, J Li… - Frontiers in …, 2019 - frontiersin.org
A periodized (14 days on/14 days off) 5% low protein-high carbohydrate (pLPHC) diet
protects against weight gain, improves glucose tolerance in mice and interacts with …

The effects of exercise training induced calories expenditure on type 2 diabetes related cardio metabolic physiological parameters and adipocytokines

MAM Zadeh, S Afrasyabi, ZA Mohamadi - Journal of Diabetes & Metabolic …, 2022 - Springer
Background Recently, many studies have examined the effects of various training on pro-
inflammatory and anti-inflammatory adipocytes. The results of these studies are …