Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and
chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if …

Pluripotent stem cells have the ability to undergo self‐renewal and to give rise to all cells of
the tissues of the body. However, this definition has been recently complicated by the …

The Oct4 protein, encoded by the Pou5f1 gene was the very first master gene, discovered 25
years ago, to be absolutely required for the stemness properties of murine and primate …

Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …

Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous
tissues compared to normal tissues and has regulatory roles in cell proliferation, cell …

Genome‐wide transcriptional activity involves the binding of many transcription factors (TFs)
to thousands of sites in the genome. Pioneer TFs are a class of TFs that maintain open …

Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with
self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance …

POU5F1 is a transcription factor and master regulator of cell pluripotency with indispensable
roles in early embryo development and cell lineage specification. The role of embryonic …

Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …