Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
The GCN5: its biological functions and therapeutic potentials
General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …
Context-dependent CpG methylation directs cell-specific binding of transcription factor ZBTB38
ABSTRACT DNA methylation on CpGs regulates transcription in mammals, both by
decreasing the binding of methylation-repelled factors and by increasing the binding of …
decreasing the binding of methylation-repelled factors and by increasing the binding of …
[HTML][HTML] A novel bioinformatic approach reveals cooperation between Cancer/Testis genes in basal-like breast tumors
M Laisné, B Rodgers, S Benlamara, J Wicinski… - Oncogene, 2024 - nature.com
Breast cancer is the most prevalent type of cancer in women worldwide. Within breast
tumors, the basal-like subtype has the worst prognosis, prompting the need for new tools to …
tumors, the basal-like subtype has the worst prognosis, prompting the need for new tools to …
Histone H3K9 methyltransferase SETDB1 augments invadopodia formation to promote tumor metastasis
S Ueshima, J Fang - Oncogene, 2022 - nature.com
Non-small cell lung cancer (NSCLC) is one of leading causes of cancer-related mortality
worldwide, which harbors various accumulated genetic and epigenetic abnormalities …
worldwide, which harbors various accumulated genetic and epigenetic abnormalities …
[HTML][HTML] Large-scale chromatin rearrangements in cancer
Simple Summary Cancers have many genetic mutations such as nucleotide changes,
deletions, amplifications, and chromosome gains or losses. Some of these genetic …
deletions, amplifications, and chromosome gains or losses. Some of these genetic …
Discovery of multi-state gene cluster switches determining the adaptive mitochondrial and metabolic landscape of breast cancer
M Menegollo, RB Bentham, T Henriques, S Qi Ng… - bioRxiv, 2023 - biorxiv.org
Adaptive metabolic switches are proposed to underlie conversions between cellular states
during normal development as well as in cancer evolution, where they represent important …
during normal development as well as in cancer evolution, where they represent important …
A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state
Epigenetic mechanisms are essential to establish and safeguard cellular identities in
mammals. They dynamically regulate the expression of genes, transposable elements, and …
mammals. They dynamically regulate the expression of genes, transposable elements, and …
Cancer/Testis genes are predictive of breast tumor subtypes
M Laisné, S Benlamara, A Nicolas, L Djerroudi… - bioRxiv, 2021 - biorxiv.org
Breast cancer is the most prevalent type of cancer in women worldwide. Within breast
tumors, the basal-like subtype has the worst prognosis and no dedicated therapy, therefore …
tumors, the basal-like subtype has the worst prognosis and no dedicated therapy, therefore …
[HTML][HTML] Aberrant activation of five embryonic stem cell-specific genes robustly predicts a high risk of relapse in breast cancers
E Jacquet, F Chuffart, AL Vitte, E Nika, M Mousseau… - BMC genomics, 2023 - Springer
Background In breast cancer, as in all cancers, genetic and epigenetic deregulations can
result in out-of-context expressions of a set of normally silent tissue-specific genes. The …
result in out-of-context expressions of a set of normally silent tissue-specific genes. The …