Abstract Development of a cancer is a multistep process and six major hallmarks of cancer
that are known to control malignant transformation have been described. Anticancer drug …

Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the
attention of medicinal chemistry due to the great variety of biological activities that they …

In this research, the new hydrazine‐1‐carbothioamides (IC32 and IC34) having
unsubstituted benzimidazole skeleton were converted to 1, 2, 4‐triazole derivatives (IC42 …

The bioisosteres of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles are well-known
pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1, 3, 4 …

Herein, we reported the synthesis of nineteen novel 1, 2, 4-triazole derivatives including 1, 3-
diphenyl-2-(1H-1, 2, 4-triazol-1-yl) propan-1-ones (7a-e), 1-(1, 3-diphenylpropan-2-yl)-1 H-1 …

Abstract A new series of 1, 3, 4-oxadiazole/chalcone hybrids was designed, synthesized,
identified with different spectroscopic techniques and biologically evaluated as inhibitors of …

Purpose Despite the availability of new drugs, many patients with acute myeloid leukemia
(AML) do not achieve remission and outcomes remain poor. Venetoclax is a promising new …

Cancer is the most severe disease worldwide. Every year, tens of millions of people are
diagnosed with cancer, and over half of those people will ultimately die from the disease …

Due to their potential as leads for various therapeutic applications, including as antimitotic
and antiparasitic agents, the development of tubulin inhibitors offers promise for drug …

In the search for new anticancer agents, we synthesized a new series of thiazole derivatives
carried on thiadiazole-oxadiazole hybrid. Final compounds (5a–5i) were analyzed via 1H …