Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen
atom as a side-chain. In addition to being a building-block for proteins, glycine is also …

Excessive energy intake and reduced energy expenditure drive the development of insulin
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …

Genome-wide association scans with high-throughput metabolic profiling provide
unprecedented insights into how genetic variation influences metabolism and complex …

Composed of hundreds of microbial species, the composition of the human gut microbiota
can vary with chronic diseases underlying health disparities that disproportionally affect …

Plasma glycine level is low in patients with obesity or diabetes and the improvement of
insulin resistance increases plasma glycine concentration. In prospective studies …

Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and
cardiometabolic disease phenotypes, but biochemical mechanisms that explain these …

Aims/hypothesis Identifying the metabolite profile of individuals with normal fasting glucose
(NFG [< 5.55 mmol/l]) who progressed to type 2 diabetes may give novel insights into early …

Identifying novel biomarkers of type 2 diabetes risk may improve prediction and prevention
among individuals at high risk of the disease and elucidate new biological pathways …