Global functions of O‐glycosylation: promises and challenges in O‐glycobiology
Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
Glycosylation of proteins is an essential process in all eukaryotes and a great diversity in
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
Direct observation of glycans bonded to proteins and lipids at the single-molecule level
Proteins and lipids decorated with glycans are found throughout biological entities, playing
roles in biological functions and dysfunctions. Current analytical strategies for these glycan …
roles in biological functions and dysfunctions. Current analytical strategies for these glycan …
Chemoenzymatic methods for the synthesis of glycoproteins
C Li, LX Wang - Chemical reviews, 2018 - ACS Publications
Glycosylation is one of the most prevalent posttranslational modifications that profoundly
affects the structure and functions of proteins in a wide variety of biological recognition …
affects the structure and functions of proteins in a wide variety of biological recognition …
An atlas of human glycosylation pathways enables display of the human glycome by gene engineered cells
Y Narimatsu, HJ Joshi, R Nason, J Van Coillie… - Molecular cell, 2019 - cell.com
The structural diversity of glycans on cells—the glycome—is vast and complex to decipher.
Glycan arrays display oligosaccharides and are used to report glycan hapten binding …
Glycan arrays display oligosaccharides and are used to report glycan hapten binding …
Display of the human mucinome with defined O-glycans by gene engineered cells
Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces
and constitute the major macromolecules in most body fluids. Mucins are primarily defined …
and constitute the major macromolecules in most body fluids. Mucins are primarily defined …
Golgi glycosylation
P Stanley - Cold Spring Harbor perspectives in biology, 2011 - cshperspectives.cshlp.org
Glycosylation is a very common modification of protein and lipid, and most glycosylation
reactions occur in the Golgi. Although the transfer of initial sugar (s) to glycoproteins or …
reactions occur in the Golgi. Although the transfer of initial sugar (s) to glycoproteins or …
The role of O-glycosylation in human disease
O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …
functional implications in both physiological and disease contexts. The biosynthesis of O …
Alterations in glycosylation as biomarkers for cancer detection
Glycoconjugates constitute a major class of biomolecules which include glycoproteins,
glycosphingolipids and proteoglycans. Glycans are involved in several physiological and …
glycosphingolipids and proteoglycans. Glycans are involved in several physiological and …
All in the family: the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferases
KG Ten Hagen, TA Fritz, LA Tabak - Glycobiology, 2003 - academic.oup.com
Mucin-type linkages (GalNAcα1-O-Ser/Thr) are initiated by a family of glycosyltransferases
known as the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases …
known as the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases …