Reversible interactions of glycoconjugates on leukocytes with P-and E-selectin on
endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the …

Cancer metastasis is facilitated by cell–cell interactions between cancer cells and
endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and …

▪ Abstract Researchers have long predicted that complex carbohydrates on cell surfaces
would play important roles in developmental processes because of the observation that …

The ability to home to extralymphoid tissues, such as the skin, lungs and gut, is acquired by
many effector and memory T cells after initial antigen encounter. This review discusses the …

▪ Abstract The four essential building blocks of cells are proteins, nucleic acids, lipids, and
glycans. Also referred to as carbohydrates, glycans are composed of saccharides that are …

Little is known about the factors that enable the mobilisation of human mesenchymal stem
cells (MSC) from the bone marrow into the blood stream and their recruitment to and …

Inflammation and cancer metastasis are associated with extravasation of leukocytes or
tumor cells from blood into tissue. Such movement is believed to follow a coordinated and …

Leukocyte recruitment encompasses cell adhesion and activation steps that enable
circulating leukocytes to roll, arrest, and firmly adhere on the endothelial surface before they …

Interactions of selectins with cell-surface glycoconjugates mediate tethering and rolling
adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped …

Integrin activation is essential for the function of all blood cells, including platelets and
leukocytes. The blood cell–specific FERM domain protein Kindlin-3 is required for the …