Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

The processes of cellular growth regulation and cellular metabolism are closely interrelated.
The c-Myc oncogene is a “master regulator” which controls many aspects of both of these …

The MYC oncoprotein is an essential transcription factor that regulates the expression of
many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is …

This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

Our recent work has shown that activation of the Ras/Raf/ERK pathway extends the half-life
of the Myc protein and thus enhances the accumulation of Myc activity. We have extended …

For more than a decade, numerous studies have suggested that the c-Myc oncogenic
protein is likely to broadly influence the composition of the transcriptome. However, the …

The number of intrinsically disordered proteins known to be involved in cell-signaling and
regulation is growing rapidly. To test for a generalized involvement of intrinsic disorder in …