Ionizing radiation-induced mutagenesis.
LH Breimer - British journal of cancer, 1988 - ncbi.nlm.nih.gov
Ionizing radiation was the first environmental agent shown to be mutagenic (Muller, 1927)
and is now recognized as a pancarcinogen (Upton, 1984; Shigematsu & Kagan, 1986). Due …
and is now recognized as a pancarcinogen (Upton, 1984; Shigematsu & Kagan, 1986). Due …
Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA
Large-scale deletions of mitochondrial DNA (mtDNA) have been described in patients with
progressive external ophthalmoplegia (PEO) and ragged red fibers. We have determined …
progressive external ophthalmoplegia (PEO) and ragged red fibers. We have determined …
Recent studies of the fidelity of DNA synthesis
TA Kunkel, K Bebenek - Biochimica et Biophysica Acta (BBA)-Gene …, 1988 - Elsevier
II. Fidelity of purified DNA polymerases........................................................... A. Base substitution
fidelity.................................................................. 1. Nucleotide selectivity of …
fidelity.................................................................. 1. Nucleotide selectivity of …
Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment
M Krawczak, DN Cooper - Human genetics, 1991 - Springer
Summary Reports describing short (< 20 bp) gene deletions causing human genetic disease
were collated in order to study underlying causative mechanisms. Deletion break-point …
were collated in order to study underlying causative mechanisms. Deletion break-point …
Instability of Simple Sequence DNA in Saccharomyces cerevisiae
ST Henderson, TD Petes - Molecular and Cellular Biology, 1992 - Taylor & Francis
All eukaryotic genomes thus far examined contain simple sequence repeats. A particularly
common simple sequence in many organisms (including humans) consists of tracts of …
common simple sequence in many organisms (including humans) consists of tracts of …
Mutagenesis by transient misalignment.
TA Kunkel, A Soni - Journal of Biological Chemistry, 1988 - ASBMB
Based upon a consideration of two mutational hot spots produced during DNA synthesis by
a eukaryotic DNA repair polymerase, we suggested that certain base substitution errors …
a eukaryotic DNA repair polymerase, we suggested that certain base substitution errors …
Recombination at the human α-globin gene cluster: sequence features and topological constraints
RD Nicholls, N Fischel-Ghodsian, DR Higgs - Cell, 1987 - cell.com
We have characterized 170 kb of DNA around the human a-globin gene cluster to enable a
systematic analysis of 12 naturally occurring deletions from this region. In 8 deletions, the …
systematic analysis of 12 naturally occurring deletions from this region. In 8 deletions, the …
Breakpoints of gross deletions coincide with non-B DNA conformations
A Bacolla, A Jaworski, JE Larson… - Proceedings of the …, 2004 - National Acad Sciences
Genomic rearrangements are a frequent source of instability, but the mechanisms involved
are poorly understood. A 2.5-kbp poly (purine· pyrimidine) sequence from the human PKD1 …
are poorly understood. A 2.5-kbp poly (purine· pyrimidine) sequence from the human PKD1 …
Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells.
AJ Grosovsky, JG De Boer… - Proceedings of the …, 1988 - National Acad Sciences
The relative role of point mutations and large genomic rearrangements in ionizing radiation-
induced mutagenesis has been an issue of long-standing interest. Recent studies using …
induced mutagenesis has been an issue of long-standing interest. Recent studies using …
Two Large Families of Chemoreceptor Genes in the NematodesCaenorhabditis elegans and Caenorhabditis briggsae Reveal Extensive Gene Duplication …
HM Robertson - Genome research, 1998 - genome.cshlp.org
The str family of genes encoding seven-transmembrane G-protein-coupled or serpentine
receptors related to the ODR-10 diacetyl chemoreceptor is very large, with at least 197 …
receptors related to the ODR-10 diacetyl chemoreceptor is very large, with at least 197 …