In vitro biosensors have been an integral component for early diagnosis of cancer in the
clinic. Among them, no-wash biosensors, which only depend on the simple mixing of the …

Proteases play a pivotal role in regulating important physiological processes from food
digestion to blood clotting. They are also important biomarkers for many diseases such as …

The therapeutic action of drugs is predicated on their physical engagement with cellular
targets. Here we describe a broadly applicable method using bioluminescence resonance …

Progress in molecular biology has made available new bioanalytical tools that take
advantage of the great detectability and the simple analytical format of bioluminescence …

FRET-based caspase activity probes have become important tools to monitor apoptotic cell
signaling. However, their dependence on external illumination is incompatible with light …

The main protease, Mpro, is critical for SARS-CoV-2 replication and an appealing target for
designing anti-SARS-CoV-2 agents. Therefore, there is a demand for the development of …

Bioluminescence resonance energy transfer (BRET) is an important tool for monitoring
macromolecular interactions and is useful as a transduction technique for biosensor …

PML, the organizer of nuclear bodies (NBs), is expressed in several isoforms designated
PMLI to VII which differ in their C-terminal region due to alternative splicing of a single gene …

Förster resonance energy transfer (RET) is the nonradiative transfer of energy from a
donor to an acceptor fluorophore. The Förster distance (R 0), being the fluorophore …

Hemostasis is an essential function that repairs tissues and maintains the survival of living
organisms. To prevent diseases caused by the abnormality of the blood coagulation …