Recent progress in engineering highly promising biocatalysts has increasingly involved
machine learning methods. These methods leverage existing experimental and simulation …

Single nucleotide variants (SNVs) contribute to human genomic diversity. Synonymous
SNVs are previously considered to be “silent,” but mounting evidence has revealed that …

The last years have witnessed remarkable advances in our understanding of the emergence
and consequences of topological constraints in biological and soft matter. Examples are …

Some misfolded protein conformations can bypass proteostasis machinery and remain
soluble in vivo. This is an unexpected observation, as cellular quality control mechanisms …

Protein representations from deep language models have yielded state-of-the-art
performance across many tasks in computational protein engineering. In recent years …

Organismal communication entails encoding a message that is sent over space or time to a
recipient cell, where that message is decoded to activate a downstream response. Defining …

The rate of protein synthesis is slower than many folding reactions and varies depending on
the synonymous codons encoding the protein sequence. Synonymous codon substitutions …

The sequence-structure-function paradigm has dominated twentieth century molecular
biology. The paradigm tacitly stipulated that for each sequence there exists a single, well …

Bacterial natural products have found many important industrial applications. Yet traditional
discovery pipelines often prioritize individual natural product families despite the presence …

During protein synthesis, the growing nascent peptide chain moves inside the polypeptide
exit tunnel of the ribosome from the peptidyl transferase center towards the exit port where it …