Neurotrophins have been implicated in the pathophysiology of many neuropsychiatric
diseases. Brain-derived neurotrophic factor (BDNF) is the most abundant and widely …

Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …

BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …

The maternal environment has a significant role in the normal development of the fetus and
may have long-term impact on brain development including critical central pathways such as …

Excitatory-inhibitory imbalance has been identified within specific brain microcircuits in
models of Rett syndrome (RTT) and other autism spectrum disorders (ASDs). However …

More than 100 single gene mutations and copy number variants convey risk for autism
spectrum disorder. To understand the extent to which each mutation contributes to the …

An emerging body of data suggests that the early onset of Alzheimer's disease (AD) is
associated with decreased brain-derived neurotrophic factor (BDNF). Because BDNF plays …

Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support
neuronal survival during development and promote connectivity and plasticity in the adult …

Background: Shared connections between physical activity and neuroprotection have been
studied for decades, but the mechanisms underlying this effect of specific exercise were only …

Human genetic studies have recently suggested that the postsynaptic activity-regulated
cytoskeleton-associated protein (Arc) complex is a convergence signal for several genes …