[HTML][HTML] A view to a kill: the bacterial type VI secretion system
The bacterial type VI secretion system (T6SS) is an organelle that is structurally and
mechanistically analogous to an intracellular membrane-attached contractile phage tail …
mechanistically analogous to an intracellular membrane-attached contractile phage tail …
[HTML][HTML] Tularaemia: bioterrorism defence renews interest in Francisella tularensis
PCF Oyston, A Sjöstedt, RW Titball - Nature Reviews Microbiology, 2004 - nature.com
Francisella tularensis is a highly infectious aerosolizable intracellular pathogen that is
capable of causing a debilitating or fatal disease with doses as low as 25 colony-forming …
capable of causing a debilitating or fatal disease with doses as low as 25 colony-forming …
[HTML][HTML] Identification of protein secretion systems in bacterial genomes
Bacteria with two cell membranes (diderms) have evolved complex systems for protein
secretion. These systems were extensively studied in some model bacteria, but the …
secretion. These systems were extensively studied in some model bacteria, but the …
Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system
S Pukatzki, AT Ma, D Sturtevant… - Proceedings of the …, 2006 - National Acad Sciences
The bacterium Vibrio cholerae, like other human pathogens that reside in environmental
reservoirs, survives predation by unicellular eukaryotes. Strains of the O1 and O139 …
reservoirs, survives predation by unicellular eukaryotes. Strains of the O1 and O139 …
Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin
S Pukatzki, AT Ma, AT Revel… - Proceedings of the …, 2007 - National Acad Sciences
Genes encoding type VI secretion systems (T6SS) are widely distributed in pathogenic Gram-
negative bacterial species. In Vibrio cholerae, T6SS have been found to secrete three …
negative bacterial species. In Vibrio cholerae, T6SS have been found to secrete three …
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
JW Jones, N Kayagaki, P Broz… - Proceedings of the …, 2010 - National Acad Sciences
Macrophages respond to cytosolic nucleic acids by activating cysteine protease caspase-1
within a complex called the inflammasome. Subsequent cleavage and secretion of …
within a complex called the inflammasome. Subsequent cleavage and secretion of …
Contact-dependent interbacterial antagonism mediated by protein secretion machines
To establish and maintain an ecological niche, bacteria employ a wide range of pathways to
inhibit the growth of their microbial competitors. Some of these pathways, such as those that …
inhibit the growth of their microbial competitors. Some of these pathways, such as those that …
[HTML][HTML] Comparative review of Francisella tularensis and Francisella novicida
LC Kingry, JM Petersen - Frontiers in cellular and infection …, 2014 - frontiersin.org
Francisella tularensis is the causative agent of the acute disease tularemia. Due to its
extreme infectivity and ability to cause disease upon inhalation, F. tularensis has been …
extreme infectivity and ability to cause disease upon inhalation, F. tularensis has been …
Molecular mechanisms of inflammasome activation during microbial infections
P Broz, DM Monack - Immunological reviews, 2011 - Wiley Online Library
The innate immune system plays a crucial role in the rapid recognition and elimination of
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
The bacterial type VI secretion machine: yet another player for protein transport across membranes
Several secretion systems have evolved that are widespread among Gram-negative
bacteria. Recently, a new secretion system was recognized, which is named the type VI …
bacteria. Recently, a new secretion system was recognized, which is named the type VI …