Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and
strawberries. The beneficial effects of phloretin are mainly associated with its potent …

Autophagy is an important cellular process, involving the transportation of cytoplasmic
contents in the double membrane vesicles to lysosomes for degradation. Autophagy …

Increasing data suggest a crucial role of circadian rhythm in regulating metabolic and
neurological diseases, and Bmal1 is regarded as a key regulator of circadian transcription …

Molecular docking revealed curcumin as a potent CB2 cannabinoid receptor (CB2R)
agonist. Since CB2R is involved in cardioprotective functions, we explored its role in …

Diabetes associated oxidative stress and impaired cholinergic neurotransmission causes
cognitive deficits. Although phloridzin shows antioxidant-and insulin sensitizing-activities, its …

Cognitive decline, an important comorbidity of type 2 diabetes (T2D), is attributed to
oxidative stress and impaired cholinergic signaling in the brain. The α7 nicotinic …

Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for
diabetes. Here, we showed that banana starch administered to diabetic rats improved …

Background Depression is a state of low mood and aversion to activity, which affects a
person's thoughts, behavior, motivation, feelings, and sense of wellbeing. Pharmacologic …

Background Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by
hyperglycemia and progressive cognitive dysfunction, and our clinical investigation revealed …

Malus hupehensis (MH), as a natural resource, contains various active ingredients such as
polyphenols, polysaccharides, proteins, amino acids, volatile substances, and other …