β− Arrestins: structure, function, physiology, and pharmacological perspectives
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …
are multifunctional intracellular proteins that regulate the activity of a very large number of …
[HTML][HTML] Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
JA McCubrey, LS Steelman, FE Bertrand, NM Davis… - Leukemia, 2014 - nature.com
Abstract Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a
complex array of critical cellular processes. It was initially identified in rat skeletal muscle as …
complex array of critical cellular processes. It was initially identified in rat skeletal muscle as …
Fulfilling the promise of" biased" G protein–coupled receptor agonism
LM Luttrell, S Maudsley, LM Bohn - Molecular pharmacology, 2015 - ASPET
The fact that over 30% of current pharmaceuticals target heptahelical G protein–coupled
receptors (GPCRs) attests to their tractability as drug targets. Although GPCR drug …
receptors (GPCRs) attests to their tractability as drug targets. Although GPCR drug …
Aptamers: Uptake mechanisms and intracellular applications
The structural flexibility and small size of aptamers enable precise recognition of cellular
elements for imaging and therapeutic applications. The process by which aptamers are …
elements for imaging and therapeutic applications. The process by which aptamers are …
Emerging functional divergence of β-arrestin isoforms in GPCR function
G protein-coupled receptors (GPCRs) are tightly regulated by multifunctional protein β-
arrestins. Two isoforms of β-arrestin sharing more than 70% sequence identity and overall …
arrestins. Two isoforms of β-arrestin sharing more than 70% sequence identity and overall …
[HTML][HTML] GPCRs in cancer: protease-activated receptors, endocytic adaptors and signaling
G protein-coupled receptors (GPCRs) are a large diverse family of cell surface signaling
receptors implicated in various types of cancers. Several studies indicate that GPCRs control …
receptors implicated in various types of cancers. Several studies indicate that GPCRs control …
Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic …
H Sic, H Kraus, J Madl, KA Flittner… - Journal of Allergy and …, 2014 - Elsevier
Background Five different G protein–coupled sphingosine-1-phosphate (S1P) receptors
(S1P1-S1P5) regulate a variety of physiologic and pathophysiologic processes, including …
(S1P1-S1P5) regulate a variety of physiologic and pathophysiologic processes, including …
[HTML][HTML] Therapeutic potential of targeting ß-arrestin
ß-arrestins are multifunctional proteins that modulate heptahelical 7 transmembrane
receptors, also known as G protein-coupled receptors (GPCRs), a superfamily of receptors …
receptors, also known as G protein-coupled receptors (GPCRs), a superfamily of receptors …
[HTML][HTML] New routes in GPCR/β-arrestin-driven signaling in cancer progression and metastasis
Tumor cells acquire invasive and metastatic behavior by sensing changes in the localization
and activation of signaling pathways, which in turn determine changes in actin cytoskeleton …
and activation of signaling pathways, which in turn determine changes in actin cytoskeleton …
[HTML][HTML] Oligonucleotide aptamer-mediated precision therapy of hematological malignancies
S Yang, H Li, L Xu, Z Deng, W Han, Y Liu… - … Therapy-Nucleic Acids, 2018 - cell.com
Precision medicine has recently emerged as a promising strategy for cancer therapy
because it not only specifically targets cancer cells but it also does not have adverse effects …
because it not only specifically targets cancer cells but it also does not have adverse effects …