Recent advances in the monitoring, modelling and control of crystallization systems

ZK Nagy, G Fevotte, H Kramer, LL Simon - Chemical Engineering Research …, 2013 - Elsevier
Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …

Advances and new directions in crystallization control

ZK Nagy, RD Braatz - Annual review of chemical and …, 2012 - annualreviews.org
The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

Assessment of recent process analytical technology (PAT) trends: a multiauthor review

LL Simon, H Pataki, G Marosi, F Meemken… - … Process Research & …, 2015 - ACS Publications
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

[HTML][HTML] Applications of machine vision in pharmaceutical technology: A review

DL Galata, LA Meszaros, N Kallai-Szabo… - European Journal of …, 2021 - Elsevier
The goal of this paper is to give an introduction to analysis of images acquired by a digital
camera with visible illumination and to review its applications as a Process Analytical …

A review of experimental methods for nucleation rate determination in large-volume batch and microfluidic crystallization

C Devos, T Van Gerven, S Kuhn - Crystal growth & design, 2021 - ACS Publications
Determination of the experimental nucleation rate for crystallization in solution has been
acknowledged as an important topic for a long time, as it improves the design and control of …

Continuous sonocrystallization of acetylsalicylic acid (ASA): Control of crystal size

RJP Eder, S Schrank, MO Besenhard… - Crystal growth & …, 2012 - ACS Publications
A continuous tubular crystallizer system with an inner diameter of 2.0 mm and an overall
length of 27 m was used to generate acetylsalicylic acid seeds in situ from ethanolic solution …

Comparative investigation of supersaturation and automated direct nucleation control of crystal size distributions using ATR-UV/vis spectroscopy and FBRM

AN Saleemi, CD Rielly, ZK Nagy - Crystal Growth & Design, 2012 - ACS Publications
The paper presents a thorough evaluation of different control strategies used in cooling
crystallization, namely, unseeded linear cooling, seeded linear cooling, supersaturation …

Image Analysis for In-line Measurement of Multidimensional Size, Shape, and Polymorphic Transformation of l-Glutamic Acid Using Deep Learning-Based Image …

Z Gao, Y Wu, Y Bao, J Gong, J Wang… - Crystal Growth & …, 2018 - ACS Publications
In situ tracking of the crystallization process through image segmentation has been
developed and has encountered many challenges including improvement of in situ image …

A critical review on thermodynamic and hydrodynamic modeling and simulation of liquid antisolvent crystallization of pharmaceutical compounds

AK Thakur, R Kumar, VKV Kumar, A Kumar… - Journal of Molecular …, 2022 - Elsevier
Fine particles are in great demand in the pharmaceutical industry due to their versatile
applications. Liquid antisolvent crystallization (LASC) is one of the promising approaches to …

Advances and opportunities concerning nucleation measurement and control technology in crystallization

F Zhang, A Meng, Y Long, ZQ Yu, S Yu… - … Process Research & …, 2024 - ACS Publications
Nucleation as a unique phenomenon in the crystallization process has always been a hot
topic. With the development of nucleation theory and process analysis technology (PAT) …