DNA double-strand breaks drive genomic instability. However, it remains unknown how
these processes may affect the biomechanical properties of the nucleus and what role …

Nucleosomes, the fundamental units of chromatin, regulate readout and expression of
eukaryotic genomes. Single-molecule experiments have revealed force-induced …

Chromatin is the epigenomic platform for diverse nuclear processes such as DNA repair,
replication, transcription, telomere, and centromere function. In cancer cells, mutations in key …

Chromatin accessibility is modulated in a variety of ways to create open and closed
chromatin states, both of which are critical for eukaryotic gene regulation. At the single …

The structural integrity of the chromosomes is essential to every functional process within the
eukaryotic nuclei. Chromosomes are DNA-histone complexes essential for the inheritance of …

Extracellular vesicles (EVs) are lipid-bound nano-sized vesicles secreted by all cells. There
are emerging pieces of evidence suggesting mechanical properties of single EVs offer …