Improvements in the gene transfer vectors used in therapeutic trials have led to substantial
clinical successes in patients with serious genetic conditions, such as immunodeficiency …

Neurological disorders affecting the central nervous system (CNS) are still incompletely
understood. Many of these disorders lack a cure and are seeking more specific and effective …

Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause
respiratory infections. These viruses are particularly pathogenic in healthy and immune …

Using high-resolution MS-based proteomics in combination with multiple protease digestion,
we profiled, with on average 90% sequence coverage, all 13 viral proteins present in an …

Adenoviral vectors are crucial for gene therapy and vaccine development, offering a platform
for gene delivery into host cells. Since the discovery of adenoviruses, first-generation vectors …

Various adenovirus (AdV) vector systems have proven to be lucrative options for gene
delivery. They can serve as potential vaccine candidates for prevention of several common …

Optimal tumor cell surface expression of human leukocyte antigen (HLA) class I molecules is
essential for the presentation of tumor-associated peptides to T-lymphocytes. However, a …

Abstract Background The Empty Spiracles Homeobox (EMX-) 2 gene has been associated
with regulation of growth and differentiation in neuronal development. While recent studies …

Current first-line treatments for most cancers feature a short-list of highly potent and often
target-blind interventions, including chemotherapy, radiation, and surgical excision. These …