Smart nanomaterials for cancer diagnosis and treatment

R Singh, A Sharma, J Saji, A Umapathi, S Kumar… - Nano …, 2022 - Springer
Innovations in nanomedicine has guided the improved outcomes for cancer diagnosis and
therapy. However, frequent use of nanomaterials remains challenging due to specific …

Overcoming challenges and limitations regarding the atomic force microscopy imaging and mechanical characterization of nanofibers

SV Kontomaris, A Stylianou, G Chliveros, A Malamou - Fibers, 2023 - mdpi.com
Atomic force microscopy (AFM) is a powerful tool that enables imaging and nanomechanical
properties characterization of biological materials. Nanofibers are the structural units of …

Mapping viscoelastic properties of healthy and pathological red blood cells at the nanoscale level

G Ciasca, M Papi, S Di Claudio, M Chiarpotto… - Nanoscale, 2015 - pubs.rsc.org
In order to pass through the microcirculation, red blood cells (RBCs) need to undergo
extensive deformations and to recover the original shape. This extreme deformability is …

Mechanical and structural comparison between primary tumor and lymph node metastasis cells in colorectal cancer

V Palmieri, D Lucchetti, A Maiorana, M Papi… - Soft matter, 2015 - pubs.rsc.org
SW480 and SW620 colon carcinoma cell lines derive from primary tumour and lymph-node
metastasis of the same patient, respectively. For this reason, these cells represent an ideal …

Determining spatial variability of elastic properties for biological samples using AFM

SV Kontomaris, A Stylianou, G Chliveros, A Malamou - Micromachines, 2023 - mdpi.com
Measuring the mechanical properties (ie, elasticity in terms of Young's modulus) of
biological samples using Atomic Force Microscopy (AFM) indentation at the nanoscale has …

Collagen is crucial target protein for scleral remodeling and biomechanical change in myopia progression and control

Y Sun, Y Sha, J Yang, H Fu, X Hou, Z Li, Y Xie, G Wang - Heliyon, 2024 - cell.com
In recent decades, the prevalence of myopia has been on the rise globally, attributed to
changes in living environments and lifestyles. This increase in myopia has become a …

Atomic force microscopy nanoindentation method on collagen fibrils

SV Kontomaris, A Stylianou, A Malamou - Materials, 2022 - mdpi.com
Atomic Force Microscopy nanoindentation method is a powerful technique that can be used
for the nano-mechanical characterization of bio-samples. Significant scientific efforts have …

Molecular mechanism responsible for fibronectin-controlled alterations in matrix stiffness in advanced chronic liver fibrogenesis

A Iwasaki, K Sakai, K Moriya, T Sasaki… - Journal of Biological …, 2016 - ASBMB
Fibrosis is characterized by extracellular matrix (ECM) remodeling and stiffening. However,
the functional contribution of tissue stiffening to noncancer pathogenesis remains largely …

Molecular cues guiding matrix stiffness in liver fibrosis

T Saneyasu, R Akhtar, T Sakai - BioMed research international, 2016 - Wiley Online Library
Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth,
differentiation, and migration and are altered in the tissue remodeling following injury and …

Facile production of nanocomposites of carbon nanotubes and polycaprolactone with high aspect ratios with potential applications in drug delivery

E Niezabitowska, J Smith, MR Prestly, R Akhtar… - RSC …, 2018 - pubs.rsc.org
The geometries and surface properties of nanocarriers greatly influence the interaction
between nanomaterials and living cells. In this work we combine multiwalled carbon …