Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions
The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …
Programmed cell death tunes tumor immunity
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …
the years revealed distinctive molecular mechanisms and functional consequences of …
Oxidative stress and regulated cell death in Parkinson's disease
PA Dionísio, JD Amaral, CMP Rodrigues - Ageing research reviews, 2021 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …
Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis
The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue
injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete …
injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete …
Necroptosis: mechanisms and relevance to disease
Necroptosis is a form of regulated cell death that critically depends on receptor-interacting
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …
Mitochondrial permeability transition pore-dependent necrosis
DJ Robichaux, M Harata, E Murphy, J Karch - Journal of molecular and …, 2023 - Elsevier
Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic
cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …
cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …
Insight into crosstalk between ferroptosis and necroptosis: novel therapeutics in ischemic stroke
Y Zhou, J Liao, Z Mei, X Liu, J Ge - Oxidative Medicine and …, 2021 - Wiley Online Library
Ferroptosis is a nonapoptotic form of cell death characterized by iron‐dependent
accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of …
accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of …
Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: new insights into the mechanisms and therapeutic potentials
Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …
TNF induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit
FJ Roca, LJ Whitworth, S Redmond, AA Jones… - Cell, 2019 - cell.com
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by
releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish …
releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish …
Role of mitochondria in retinal pigment epithelial aging and degeneration
Retinal pigment epithelial (RPE) cells form a monolayer between the neuroretina and
choroid. It has multiple important functions, including acting as outer blood-retina barrier …
choroid. It has multiple important functions, including acting as outer blood-retina barrier …