The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

Myocardial infarction (MI) and heart failure (HF) are the leading causes of death in the
United States and in most other industrialized nations. MI leads to a massive loss of …

Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …

Background: Sphingolipids have recently emerged as a biomarker of recurrence and
mortality after myocardial infarction (MI). The increased ceramide levels in mammalian heart …

Abstract Lipid Nanoparticles (LNPs) are a promising drug delivery vehicle for clinical siRNA
delivery. Modified mRNA (modRNA) has recently gained great attention as a therapeutic …

Cell-based therapies offer an exciting and novel treatment for heart repair following
myocardial infarction (MI). However, these therapies often suffer from poor cell viability and …

Myocardial infarction is the first cause of worldwide mortality, with an increasing incidence
also reported in developing countries. Over the past decades, preclinical research and …

The perspective of using messenger RNA (mRNA) as a therapeutic molecule first faced
some uncertainties due to concerns about its instability and the feasibility of large-scale …

In recent years, nucleic acid-based therapeutics have gained increasing importance as
novel treatment options for disease prevention and treatment. Synthetic messenger RNAs …

Cardiovascular disease is the leading cause of death around the world, in which myocardial
infarction (MI) is a precipitating event. However, current therapies do not adequately address …