The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

There have been significant recent advances in our understanding of the mechanisms that
maintain potassium homoeostasis and the clinical consequences of hyperkalemia. In this …

When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …

Excess aldosterone is an important contributor to hypertension and cardiovascular disease.
Conversely, low circulating aldosterone causes salt wasting and hypotension. Aldosterone …

Protein modification by ubiquitination plays a key evolutionarily conserved role in regulating
membrane proteins. Nedd4-2, a ubiquitin ligase, targets membrane proteins such as ion …

With-no-lysine (WNK) kinases coordinate volume and potassium homeostasis by regulating
renal tubular electrolyte transport. In the distal convoluted tubule (DCT), potassium …

Distal tubular sodium retention is a potent driver of hypertension, and the thiazide–sensitive
sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors …

Parkinson's disease (PD) is a debilitating neurodegenerative disease that causes a great
clinical burden. However, its exact molecular pathologies are not fully understood. Whilst …

The distal nephron of the kidney has a central role in sodium and fluid homeostasis, and
disruption of this homeostasis due to mutations of with-no-lysine kinase 1 (WNK1), WNK4 …

Blood pressure (BP) normally dips during sleep, and nondipping increases cardiovascular
risk. Hydrochlorothiazide restores the dipping BP profile in nondipping patients, suggesting …