Identification of vaccine and drug targets in Shigella dysenteriae sd197 using reverse vaccinology approach

K Jalal, T Abu-Izneid, K Khan, M Abbas, A Hayat… - Scientific reports, 2022 - nature.com
Shigellosis is characterized as diarrheal disease that causes a high mortality rate especially
in children, elderly and immunocompromised patients. More recently, the World Health …

[HTML][HTML] An integrated in silico based subtractive genomics and reverse vaccinology approach for the identification of novel vaccine candidate and chimeric vaccine …

K Khan, K Jalal, R Uddin - Genomics, 2022 - Elsevier
Salmonella typhi is notorious for causing enteric fever which is also known as typhoid fever.
It emerged as an extreme drug resistant strain that requires urgent attention to prevent its …

Maintenance of bacterial outer membrane lipid asymmetry: insight into MlaA

M Kaur, MP Mingeot-Leclercq - BMC microbiology, 2024 - Springer
The outer membrane (OM) of Gram-negative bacteria acts as an effective barrier to protect
against toxic compounds. By nature, the OM is asymmetric with the highly packed …

Transcriptomic Profiles of Vibrio parahaemolyticus During Biofilm Formation

Y Zhang, T Zhang, Y Qiu, M Zhang, X Lu, W Yang… - Current …, 2023 - Springer
Vibrio parahaemolyticus, the leading cause of bacterial seafood-associated gastroenteritis,
can form biofilms. In this work, the gene expression profiles of V. parahaemolyticus during …

[HTML][HTML] Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant

K Khan, SA Khan, K Jalal, Z Ul-Haq, R Uddin - Virology, 2022 - Elsevier
The newly discovered SARS-CoV-2 Omicron variant B. 1.1. 529 is a Variant of Concern
(VOC) announced by the World Health Organization (WHO). It's becoming increasingly …

[HTML][HTML] The protective efficacy of forty outer membrane proteins based DNA vaccines against Aeromonas hydrophila in zebrafish

Y Liu, Y Wu, R Srinivasan, Z Liu, Y Wang, L Zhang… - Aquaculture …, 2022 - Elsevier
It is well known that the outer membrane proteins (OMPs) of Gram-negative bacteria are
potential vaccine candidates against bacterial infections, whereas systematic research on …

Pan genome based reverse vaccinology approach to explore Enterococcus faecium (VRE) strains for identification of novel multi-epitopes vaccine candidate

G Alotaibi, K Khan, AK Al Mouslem, SA Khan… - Immunobiology, 2022 - Elsevier
Enterococcus faecium is regarded as fourth most emerging common pathogen causing
hospital acquired infections (HAIs), with high mortality rate, especially in children, elderly …

Construction and immunological evaluation of live vector vaccine based on attenuated Listeria monocytogenes vector against Vibrio parahaemolyticus infection

Q Ji, J Ma, S Wang, Q Liu - Aquaculture, 2022 - Elsevier
Vibrio parahaemolyticus is considered to be one of the most threatening aquatic pathogens
in aquaculture. Therefore, the development of an effective vaccine is crucial to prevent and …

BacScan: a novel genome-wide strategy for uncovering broadly immunogenic proteins in bacteria

J Dong, Q Zhang, J Yang, Y Zhao, Z Miao… - Frontiers in …, 2024 - frontiersin.org
In response to the global threat posed by bacterial pathogens, which are the second leading
cause of death worldwide, vaccine development is challenged by the diversity of bacterial …

Physiology, metabolism, antibiotic resistance, and genetic diversity of Harveyi clade bacteria isolated from coastal mariculture system in China in the last two decades

H Kang, Y Yu, M Liao, Y Wang, G Yang… - Frontiers in Marine …, 2022 - frontiersin.org
Vibrio bacteria, particularly members of the Harveyi clade, are the most important pathogens
of aquatic organisms that cause significant economic losses in the world. It is difficult to …