The overall success and long-term life of the medical implants are decisively based on the
convenient osseointegration at the hosting tissue-implant interface. Therefore, various …

Technological advances have provided surgeons with a wide range of biomaterials. Yet
improvements are still to be made, especially for large bone defect treatment. Biomaterial …

Critical-sized diaphysis defects are complicated by inherent sub-optimal healing conditions.
The two-staged induced membrane technique has been used to treat these challenging …

Bioactive glass (BAG) is a synthetic bone substitute with intrinsic antimicrobial properties,
used for bone defect filling. We evaluated the antimicrobial activity of two formulations of …

In this paper, we disclose a novel biomaterial with a considerable capacity for cell growth
and bone mineralisation. The biomaterial is manufactured by sintering diatom …

Background: The treatment of large-sized bone defects remains a major challenge in trauma
and orthopaedic surgery. Although there are many treatment options, there is still no clear …

Bioactive glasses (BAG) are used as bone-graft substitutes in orthopaedic surgery. A
specific BAG scaffold was developed by sintering BAG-S53P4 granules. It is hypothesised …

Bone nonunion following a fracture represents a significant global healthcare challenge,
with an overall incidence ranging between 2 and 10% of all fractures. The management of …

Introduction Treatment of infected non-unions of the tibia is a challenging problem. The
cornerstones of optimal infected non-union treatment consist of extensive debridement …

Currently, the apatite-forming ability evaluation of a biomaterial employs Kokubo's simulated
body fluid (SBF) as a testing medium. As the conventional SBF simulates only the ionic …