Purpose To perform an individual patient data (IPD) meta-analysis of randomized controlled
trials evaluating stereotactic radiosurgery (SRS) with or without whole-brain radiation …

In the past decade, the characterization of non-small-cell lung cancer (NSCLC) into
subtypes based on genotype and histology has resulted in dramatic improvements in …

Background Immunotherapy targeting the PD-1 axis has activity in several tumour types. We
aimed to establish the activity and safety of the PD-1 inhibitor pembrolizumab in patients …

Purpose Stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal
growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for …

Mutations in the epidermal growth factor receptor gene (EGFR) represent one of the most
frequent “actionable” alterations in non–small cell lung cancer (NSCLC). Typified by high …

Background Lung cancer is the most common cause of cancer-related mortality in humans.
There are several reasons for this high rate of mortality, including metastasis to several …

Importance It remains uncertain whether treatment with stereotactic radiosurgery (SRS)
alone can be safely applied to all patient populations with 1 to 4 brain metastases (BMs) …

Purpose To perform a retrospective analysis of patients with epidermal growth factor
receptor (EGFR)-mutant lung adenocarcinoma who developed brain metastases (BM) to …

Cancer is one of the leading non-communicable diseases with highest mortality rates
worldwide. About half of all cancer patients receive radiation treatment in the course of their …

The incidence of brain metastases in patients with lung cancer has increased as a result of
improved local and systemic control and better diagnosis from advances in brain imaging …