Reactive arthritis (ReA) is an inflammatory arthritis that arises after certain types of
gastrointestinal or genitourinary infections, representing the classic interplay of host and …

Ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the pathogenesis of
which is poorly understood. The mechanism by which the main gene for the disease, HLA …

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which
HLA-B* 27 is the major genetic risk factor, although its role in the aetiology of AS remains …

Abstract Purpose of Review The aim of this paper is to provide an overview about reactive
arthritis, with an update regarding pathophysiology and therapeutic approach of the disease …

Modern technological innovations have advanced our understanding of the genetic basis of
spondyloarthritis. In ankylosing spondylitis (AS), where the major histocompatibility complex …

The findings suggest that further genome-wide studies in large case–control cohorts are
likely to be very productive in this disease. The IL23R findings and subsequent …

The term spondyloarthritis (SpA) encompasses a group of chronic inflammatory diseases
with common features in terms of clinical presentation and genetic predisposition. SpA is …

The pathogenesis of reactive arthritis (ReA) has not been fully elucidated. In recent years,
many researchers have confirmed that multiple cytokines are involved in the occurrence and …

The HLA-B27 molecule is one of the most fascinating in medicine. Its contribution to the
aetiopathogenesis of SpA and other diseases, and its protective action in certain infections …

Major histocompatibility complex (MHC) class I proteins are expressed on the cell surface
where they present foreign and self-peptides to effector cells of the immune system. While …