Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

The appearance and spread of antibiotic-resistant pathogens known as antimicrobial
resistance (AMR) is one of the major worldwide health crises that humanity have to deal with …

A depleted antimicrobial drug pipeline combined with an increasing prevalence of Gram-
negative 'superbugs' has increased interest in nano therapies to treat antibiotic resistance …

Background We isolated the carbapenemase-producing Enterobacteriaceae (CPE) strains
from children during 2016–2021 in Shanghai, China and investigated the antimicrobial …

Polymyxins have resurged as the last-resort antibiotics against multidrug-resistant
Acinetobacter baumannii. As reports of polymyxin resistance in A. baumannii with …

Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat.
In recent times, increased rates of resistance have been reported not only to commonly used …

We have demonstrated that ivacaftor displays synergistic antibacterial activity in combination
with polymyxin B against polymyxin-resistant Pseudomonas aeruginosa that commonly …

Antimicrobial-resistant (AMR) infections pose a serious risk to human and animal health. A
major factor contributing to this global crisis is the sharing of resistance genes between …

Staphylococcus aureus is a major human pathogen, and the appearance of methicillin-
resistant S. aureus (MRSA) renders S. aureus infections more challenging to treat …

This study aimed to investigate synergistic antibacterial activity of polymyxin B in
combination with the selective serotonin reuptake inhibitor, sertraline, against the Gram …