Mendelian randomization for nephrologists
Confounding is a major limitation of observational studies. Mendelian randomization (MR) is
a powerful study design that uses genetic variants as instrumental variables to enable …
a powerful study design that uses genetic variants as instrumental variables to enable …
Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities
IM McGrath, GW Montgomery… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Endometriosis remains a poorly understood disease, despite its high
prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of …
prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of …
Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation
We introduce MetaboAnalyst version 6.0 as a unified platform for processing, analyzing, and
interpreting data from targeted as well as untargeted metabolomics studies using liquid …
interpreting data from targeted as well as untargeted metabolomics studies using liquid …
Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study
HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are
recognized as distinct entities. There remains uncertainty surrounding the causal effects of …
recognized as distinct entities. There remains uncertainty surrounding the causal effects of …
Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes
Cow's milk is frequently included in the human diet, but the relationship between milk intake
and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic …
and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic …
mGWAS-Explorer 2.0: Causal Analysis and Interpretation of Metabolite–Phenotype Associations
Metabolomics-based genome-wide association studies (mGWAS) are key to understanding
the genetic regulations of metabolites in complex phenotypes. We previously developed …
the genetic regulations of metabolites in complex phenotypes. We previously developed …
The genetic architecture of biological age in nine human organ systems
Investigating the genetic underpinnings of human aging is essential for unraveling the
etiology of and developing actionable therapies for chronic diseases. Here, we characterize …
etiology of and developing actionable therapies for chronic diseases. Here, we characterize …
Bayesian-based analysis of the causality between 731 immune cells and erectile dysfunction: a two-sample, bidirectional, and multivariable Mendelian randomization …
J Chen, Y Liu, P Zhan, T Gao, J Zuo, X Li… - Sexual …, 2024 - academic.oup.com
Background The causal relationship between certain immune cells and erectile dysfunction
(ED) is still uncertain. Aim The study sought to investigate the causal effect of 731 types of …
(ED) is still uncertain. Aim The study sought to investigate the causal effect of 731 types of …
Does gestational diabetes mellitus increase the risk of cardiovascular disease? A Mendelian randomization study
W Liang, FF Sun - Journal of Endocrinological Investigation, 2024 - Springer
Purpose In recent years, epidemiological studies have revealed the relationship between
gestational diabetes mellitus (GDM) and cardiovascular disease (CVD). In this study, we …
gestational diabetes mellitus (GDM) and cardiovascular disease (CVD). In this study, we …