Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …

Summary Hyperpolarizing GABA AR currents, the unitary events that underlie synaptic
inhibition, are dependent upon efficient Cl− extrusion, a process that is facilitated by the …

Inhibitory GABA-ergic neurotransmission is fundamental for the adult vertebrate central
nervous system and requires low chloride concentration in neurons, maintained by KCC2, a …

K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal
function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory …

Cardiovascular diseases, the leading life-threatening conditions, involve cardiac arrhythmia,
coronary artery disease, myocardial infarction, heart failure, cardiomyopathy, and heart …

In this study, based on the excitatory/inhibitory imbalance theory of autism, the time window
of GABA switch, the role of K‐Cl co‐transporter 2 (KCC2) in adjustment GABA switch, and …

Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic
and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from …

Objective Altered expression patterns of Na+-K+-2Cl–(NKCC1) and K+-Cl–(KCC2) co-
transporters have been implicated in the pathogenesis of epilepsy. Here, we assessed the …

Background In neonatal mice, anesthesia with sevoflurane depolarizes the GABA Type A
receptor (GABAAR), which leads to cognitive impairment. Calcium accumulation in neurons …

Impaired inhibitory signaling underlies the pathophysiology of many neuropsychiatric and
neurodevelopmental disorders including autism spectrum disorders and epilepsy. Neuronal …