Molecular mechanisms of disease-causing missense mutations
Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …
on stability, hydrogen bond network, conformational dynamics, activity and many other …
Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …
mutations on function from a structural perspective. Proteins evolve under the law of natural …
[HTML][HTML] Proteins feel more than they see: fine-tuning of binding affinity by properties of the non-interacting surface
PL Kastritis, JP Rodrigues, GE Folkers… - Journal of molecular …, 2014 - Elsevier
Protein–protein complexes orchestrate most cellular processes such as transcription, signal
transduction and apoptosis. The factors governing their affinity remain elusive however …
transduction and apoptosis. The factors governing their affinity remain elusive however …
Advances in translational bioinformatics: computational approaches for the hunting of disease genes
MG Kann - Briefings in bioinformatics, 2010 - academic.oup.com
Over a 100 years ago, William Bateson provided, through his observations of the
transmission of alkaptonuria in first cousin offspring, evidence of the application of …
transmission of alkaptonuria in first cousin offspring, evidence of the application of …
[HTML][HTML] Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: A molecular dynamics study
Bacterial resistance is a serious threat to human health. The production of β-lactamase,
which inactivates β-lactams is most common cause of resistance to the β-lactam antibiotics …
which inactivates β-lactams is most common cause of resistance to the β-lactam antibiotics …
[HTML][HTML] Stability of domain structures in multi-domain proteins
RM Bhaskara, N Srinivasan - Scientific reports, 2011 - nature.com
Multi-domain proteins have many advantages with respect to stability and folding inside
cells. Here we attempt to understand the intricate relationship between the domain-domain …
cells. Here we attempt to understand the intricate relationship between the domain-domain …
[HTML][HTML] Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset
The 1000 Genomes Project data provides a natural background dataset for amino acid
germline mutations in humans. Since the direction of mutation is known, the amino acid …
germline mutations in humans. Since the direction of mutation is known, the amino acid …
[HTML][HTML] Computer-aided protein directed evolution: a review of web servers, databases and other computational tools for protein engineering
The combination of computational and directed evolution methods has proven a winning
strategy for protein engineering. We refer to this approach as computer-aided protein …
strategy for protein engineering. We refer to this approach as computer-aided protein …
[HTML][HTML] Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database
Background Structural studies are increasingly providing huge amounts of information on
multi-protein assemblies. Although a complete understanding of cellular processes will be …
multi-protein assemblies. Although a complete understanding of cellular processes will be …
Statistical potentials for improved structurally constrained evolutionary models
Assessing the influence of three-dimensional protein structure on sequence evolution is a
difficult task, mainly because of the assumption of independence between sites required by …
difficult task, mainly because of the assumption of independence between sites required by …