Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …
tissue and cell functions and significant increases in the risks of various aging-related …
Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Gut microbiota in human metabolic health and disease
Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
The gut microbiota in obesity and weight management: microbes as friends or foe?
Obesity is caused by a long-term difference between energy intake and expenditure—an
imbalance that is seemingly easily restored by increasing exercise and reducing caloric …
imbalance that is seemingly easily restored by increasing exercise and reducing caloric …
Benefits of metformin in attenuating the hallmarks of aging
AS Kulkarni, S Gubbi, N Barzilai - Cell metabolism, 2020 - cell.com
Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …
[HTML][HTML] Gut microbiome: profound implications for diet and disease
The gut microbiome plays an important role in human health and influences the
development of chronic diseases ranging from metabolic disease to gastrointestinal …
development of chronic diseases ranging from metabolic disease to gastrointestinal …
The gut microbiome and metabolic syndrome
K Dabke, G Hendrick, S Devkota - The Journal of clinical …, 2019 - Am Soc Clin Investig
The metabolic syndrome (MetS) is a constellation of risk factors that, if left untreated, will
often progress to greater metabolic defects such as type 2 diabetes and nonalcoholic fatty …
often progress to greater metabolic defects such as type 2 diabetes and nonalcoholic fatty …
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
GDF15 mediates the effects of metformin on body weight and energy balance
Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …
You are what you eat: diet, health and the gut microbiota
Since the renaissance of microbiome research in the past decade, much insight has
accumulated in comprehending forces shaping the architecture and functionality of resident …
accumulated in comprehending forces shaping the architecture and functionality of resident …