Exploring the frontiers of therapeutic breadth of antifungal peptides: A new avenue in antifungal drugs

I Ul Haq, S Maryam, DY Shyntum… - Journal of Industrial …, 2024 - academic.oup.com
The growing prevalence of fungal infections alongside rising resistance to antifungal drugs
poses a significant challenge to public health safety. At the close of the 2000s, major …

Use of defensins to develop eco-friendly alternatives to synthetic fungicides to control phytopathogenic fungi and their mycotoxins

V Leannec-Rialland, V Atanasova, S Chereau… - Journal of Fungi, 2022 - mdpi.com
Crops are threatened by numerous fungal diseases that can adversely affect the availability
and quality of agricultural commodities. In addition, some of these fungal phytopathogens …

Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

MJA Hein, M Kvansakul, FT Lay… - Biochemical Society …, 2022 - portlandpress.com
Defensins are a class of host defence peptides (HDPs) that often harbour antimicrobial and
anticancer activities, making them attractive candidates as novel therapeutics. In comparison …

Health implications and nutrient bioavailability of bioactive compounds in dry beans and other pulses

JA Wiesinger, F Marsolais… - Dry beans and pulses …, 2022 - Wiley Online Library
Pulse crops produced for direct human consumption (dry bean, dry pea, lentil, and chickpea)
are an important source of protein and complex carbohydrates for millions living throughout …

Antifungal Activity, Structural Stability, and Immunomodulatory Effects on Human Immune Cells of Defensin from the Lentil Lens culinaris

EI Finkina, IV Bogdanov, AA Ignatova, MD Kanushkina… - Membranes, 2022 - mdpi.com
An increase in the frequency of mycoses and spreading of multidrug-resistant fungal
pathogens necessitates the search for new antifungal agents. Earlier, we isolated the novel …

The C-terminus of panusin, a lobster β-defensin, is crucial for optimal antimicrobial activity and serum stability

R Bello-Madruga, J Valle, MÁ Jiménez, M Torrent… - Pharmaceutics, 2023 - mdpi.com
β-defensins are one of the most abundant and studied families of antimicrobial peptides
(AMPs). Because of their selective toxicity to bacterial membranes and a broad spectrum of …

Natural phytoalexins inspired the discovery of new biphenyls as potent antifungal agents for treatment of invasive fungal infections

JC Liu, J Yang, SX Lei, MF Wang, YN Ma… - European Journal of …, 2023 - Elsevier
With the aim of discovering novel and effective antifungal agents derived from natural
sources, a series of new biphenyls based on natural biphenyl phytoalexins were designed …

Fighting pathogenic yeasts with plant defensins and anti-fungal proteins from fungi

P Manzanares, M Giner-Llorca, JF Marcos… - Applied microbiology …, 2024 - Springer
Fungal infections represent a significant health risk worldwide. Opportunistic infections
caused by yeasts, particularly by Candida spp. and their virulent emerging isolates, have …

Antifungal Plant Defensins as an Alternative Tool to Combat Candidiasis

EI Finkina, OV Shevchenko, SI Fateeva, AA Tagaev… - Plants, 2024 - mdpi.com
Currently, the spread of fungal infections is becoming an urgent problem. Fungi of the
Candida genus are opportunistic microorganisms that cause superficial and life-threatening …

Recent Discoveries of Antifungal Activity in Plant Antimicrobial Peptides

MCM Ceron, RG Vitale, SL Giudicessi - International Journal of Peptide …, 2024 - Springer
Abstract Background Antimicrobial peptides (AMPs) are positive-charged small molecules of
less than 50 amino acids, with antibacterial and antifungal properties. The main mechanism …