Navigating the temporal continuum of effective population size
K Nadachowska‐Brzyska, M Konczal… - Methods in Ecology …, 2022 - Wiley Online Library
Effective population size, Ne, is a key evolutionary parameter that determines the levels of
genetic variation and efficacy of selection. Estimation and interpretation of Ne are essential …
genetic variation and efficacy of selection. Estimation and interpretation of Ne are essential …
Toward a new history and geography of human genes informed by ancient DNA
JK Pickrell, D Reich - Trends in Genetics, 2014 - cell.com
Genetic information contains a record of the history of our species, and technological
advances have transformed our ability to access this record. Many studies have used …
advances have transformed our ability to access this record. Many studies have used …
[HTML][HTML] Human demographic history impacts genetic risk prediction across diverse populations
The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …
Europeans, and their transferability to other populations is dependent on many factors (eg …
Robust inference of population structure for ancestry prediction and correction of stratification in the presence of relatedness
Population structure inference with genetic data has been motivated by a variety of
applications in population genetics and genetic association studies. Several approaches …
applications in population genetics and genetic association studies. Several approaches …
Global diversity, population stratification, and selection of human copy-number variation
INTRODUCTION Most studies of human genetic variation have focused on single-nucleotide
variants (SNVs). However, copy-number variants (CNVs) affect more base pairs of DNA …
variants (SNVs). However, copy-number variants (CNVs) affect more base pairs of DNA …
Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos
MP Conomos, CA Laurie, AM Stilp, SM Gogarten… - The American Journal of …, 2016 - cell.com
US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …
exposures. Here, we characterized and controlled for this diversity in genome-wide …
[HTML][HTML] Integrated analysis of genetic ancestry and genomic alterations across cancers
Disparities in cancer care have been a long-standing challenge. We estimated the genetic
ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the …
ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the …
Genomic insights into the ancestry and demographic history of South America
South America has a complex demographic history shaped by multiple migration and
admixture events in pre-and post-colonial times. Settled over 14,000 years ago by Native …
admixture events in pre-and post-colonial times. Settled over 14,000 years ago by Native …
Inferring the joint demographic history of multiple populations: beyond the diffusion approximation
J Jouganous, W Long, AP Ragsdale, S Gravel - Genetics, 2017 - academic.oup.com
Patterns of genetic variation across populations are influenced by mutation, selection,
genetic drift, and migrations. Building models of evolution... Understanding variation in allele …
genetic drift, and migrations. Building models of evolution... Understanding variation in allele …
The gut microbiota of Colombians differs from that of Americans, Europeans and Asians
Background The composition of the gut microbiota has recently been associated with health
and disease, particularly with obesity. Some studies suggested a higher proportion of …
and disease, particularly with obesity. Some studies suggested a higher proportion of …