Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Skeletal muscle is composed of a large and heterogeneous assortment of cell populations
that interact with each other to maintain muscle homeostasis and orchestrate regeneration …

Immunotherapies have achieved remarkable successes in the treatment of cancer, but major
challenges remain,. An inherent weakness of current treatment approaches is that …

IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …

Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …

During homeostasis, interactions between tolerogenic dendritic cells (DCs), self-reactive T
cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance …

Summary The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory
and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched …

FOXP3+ regulatory T cells (Treg cells) are a specialized population of CD4+ T cells that
restrict immune activation and are essential to prevent systemic autoimmunity. In the …

Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …