Prevalence and incidence of Huntington's disease: an updated systematic review and meta‐analysis
A Medina, Y Mahjoub, L Shaver… - Movement …, 2022 - Wiley Online Library
The incidence and prevalence of Huntington's disease (HD) based on a systematic review
and meta‐analysis of 20 studies published from 1985 to 2010 was estimated at 0.38 per …
and meta‐analysis of 20 studies published from 1985 to 2010 was estimated at 0.38 per …
Inflammation in CNS neurodegenerative diseases
J Stephenson, E Nutma, P van der Valk, S Amor - Immunology, 2018 - Wiley Online Library
Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …
increased attention as they impose a considerable socioeconomic impact, due in part to the …
A survey of healthcare Internet of Things (HIoT): A clinical perspective
In combination with current sociological trends, the maturing development of Internet of
Things devices is projected to revolutionize healthcare. A network of body-worn sensors …
Things devices is projected to revolutionize healthcare. A network of body-worn sensors …
Drug repurposing for rare diseases
HI Roessler, NVAM Knoers, MM van Haelst… - Trends in …, 2021 - cell.com
Currently, there are about 7000 identified rare diseases, together affecting 10% of the
population. However, fewer than 6% of all rare diseases have an approved treatment option …
population. However, fewer than 6% of all rare diseases have an approved treatment option …
Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies
Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …
oxidative stress have been greatly implicated in the progression of aging, along with the …
[HTML][HTML] Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders
Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …
New avenues for the treatment of Huntington's disease
A Kim, K Lalonde, A Truesdell, P Gomes Welter… - International journal of …, 2021 - mdpi.com
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
Increased frequency of repeat expansion mutations across different populations
Repeat expansion disorders (REDs) are a devastating group of predominantly neurological
diseases. Together they are common, affecting 1 in 3,000 people worldwide with population …
diseases. Together they are common, affecting 1 in 3,000 people worldwide with population …
CRISPR-Cas9-mediated genome editing increases lifespan and improves motor deficits in a Huntington's disease mouse model
FK Ekman, DS Ojala, MM Adil, PA Lopez… - … Therapy-Nucleic Acids, 2019 - cell.com
Huntington's disease (HD) is a currently incurable and, ultimately, fatal neurodegenerative
disorder caused by a CAG trinucleotide repeat expansion within exon 1 of the huntingtin …
disorder caused by a CAG trinucleotide repeat expansion within exon 1 of the huntingtin …
[HTML][HTML] Role of plant derived alkaloids and their mechanism in neurodegenerative disorders
Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …
of neurons. Conventional as well as newer molecules have been tested but they offer just …