5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …
thiazolidinones being a widely studied class of small molecules used in modern organic and …
Recent developments with rhodanine as a scaffold for drug discovery
D Kaminskyy, A Kryshchyshyn… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …
privileged heterocycles in medicinal chemistry. The main achievements include the …
The race to bash NASH: emerging targets and drug development in a complex liver disease
FA Romero, CT Jones, Y Xu, M Fenaux… - Journal of medicinal …, 2020 - ACS Publications
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …
(NAFLD) characterized by liver steatosis, inflammation, and hepatocellular damage. NASH …
Small-molecule inhibitors targeting apoptosis signal-regulated kinase 1
T Wang, L Pang, M He, Z Wang - European Journal of Medicinal Chemistry, 2023 - Elsevier
Apoptosis signal regulated kinase 1 (ASK1, also known as MAP3K5) is a member of the
mitogen activated protein kinase kinase kinase (MAP3K) family. Since its first isolation from …
mitogen activated protein kinase kinase kinase (MAP3K) family. Since its first isolation from …
Pleiotropic properties of ASK1
C Sakauchi, H Wakatsuki, H Ichijo, K Hattori - Biochimica et Biophysica …, 2017 - Elsevier
Background Apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated
protein kinase kinase kinase 5 (MAP3K5), has the potential to induce cellular apoptosis …
protein kinase kinase kinase 5 (MAP3K5), has the potential to induce cellular apoptosis …
Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis
S Hou, X Yang, Y Tong, Y Yang, Q Chen, B Wan… - European journal of …, 2021 - Elsevier
Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein
kinase (MAPK) family, is implicated in many human diseases. Here, we describe the …
kinase (MAPK) family, is implicated in many human diseases. Here, we describe the …
The therapeutic landscape of non‐alcoholic steatohepatitis
Non‐alcoholic steatohepatitis (NASH) is characterized by lobular inflammation and
hepatocellular ballooning, and may be associated with liver fibrosis leading to cirrhosis and …
hepatocellular ballooning, and may be associated with liver fibrosis leading to cirrhosis and …
Discovery and development of ASK1 inhibitors
R Brys, K Gibson, T Poljak, S Van Der Plas… - Progress in Medicinal …, 2020 - Elsevier
Aberrant activation of mitogen-activated protein kinases (MAPKs) like c-Jun N-terminal
kinase (JNK) and p38 is an event involved in the pathophysiology of numerous human …
kinase (JNK) and p38 is an event involved in the pathophysiology of numerous human …
Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1, 5-dihydro-pyrrol-2-one
Apoptosis signal-regulating kinase 1 (ASK1) plays important roles in the pathogenesis of
type 1 and type 2 diabetes, autoimmune disorders, cancer and neurodegenerative diseases …
type 1 and type 2 diabetes, autoimmune disorders, cancer and neurodegenerative diseases …
Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors
T Fujisawa - Advances in biological regulation, 2017 - Elsevier
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the stress-activated mitogen-
activated protein kinase kinase kinase (MAP3K) family. ASK1 is an attractive drug target …
activated protein kinase kinase kinase (MAP3K) family. ASK1 is an attractive drug target …