Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate
somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have …

The regeneration of focal articular cartilage defects is complicated by the reduced quality of
the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial …

Incorporating therapeutic genes into three-dimensional biomaterials is a promising strategy
for enhancing tissue regeneration. Alginate hydrogels have been extensively investigated …

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

The ability to develop tissue constructs with matrix composition and biomechanical
properties that promote rapid tissue repair or regeneration remains an enduring challenge in …

Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a
growing trend with the increasing life span. OA is the most prevalent joint condition …

Berberine, a plant alkaloid used in C hinese medicine, has broad cell‐protective functions in
a variety of cell lines. Chondrocyte apoptosis contributes to the pathogenesis of cartilage …

Osteoarthritis (OA) is an incapacitating and one of the most common physically degenerative
conditions with an assorted etiology and a highly complicated molecular mechanism that to …

Short stature is among the most common endocrinological disease phenotypes of childhood
and may occur as an isolated finding or in conjunction with other clinical manifestations …