The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …

The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …

The era of inexpensive genome sequencing and improved bioinformatics tools has
reenergized the study of natural products, including the ribosomally synthesized and post …

Soil contamination by toxic metals is a major health issue that could be partly solved by
using genetically-modified plants. For that, the recently developed technique of clustered …

CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as
CRISPR-BEST, have dramatically simplified genetic manipulation of streptomycetes. One …

Highlights•Bacterial CRISPR approaches are used for gene editing, repression, and
activation.•CRISPRi, which blocks transcription of targeted genes, is the main bacterial …

The CRISPR-Cas9 technology has changed the landscape of genome editing and has
demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering …

Since time immemorial, human use medicinal plants as sources of food, therapy and
industrial purpose. Classical biotechnology and recent next-generation sequencing (NGS) …

Azoxy compounds are a distinctive group of bioactive secondary metabolites characterized
by a unique RN═ N+ (O–) R moiety. The azoxy moiety is present in various classes of …

Natural products possess significant therapeutic potential but remain underutilized despite
advances in genomics and bioinformatics. While there are approaches to activate and …