The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

In this work we advance the hypothesis that omega-3 (ω-3) long-chain polyunsaturated fatty
acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number …

The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids),
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …

Background: Cannabis is the most widely used illicit substance worldwide, and legalization
for recreational and medical purposes has substantially increased its availability and use in …

The cannabinoid CB1 and CB2 receptors are Class AG protein-coupled receptors (GPCRs).
While many Class A GPCRs have endogenous ligands that are hydrophilic cations (eg, the …

BACKGROUND:: Cannabinoid receptors mediate the psychopharmacological action of
marijuana and have been localized in the central and peripheral nervous system as well as …

The major psychoactive constituent of Cannabis sativa, Δ 9-tetrahydrocannabinol (Δ 9-THC),
and endogenous cannabinoid ligands, such as anandamide, signal through G-protein …

Abstract Background and Purpose: Corneal injury can result in dysfunction of corneal
nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system …

The active principle in marijuana, Δ9-tetrahydrocannabinol (THC), has been shown to have
wide therapeutic application for a number of important medical conditions, including pain …

With increasing longevity, patients are developing more and more chronic diseases that
require treatment with medications. Yet, it is not fully understood the extent by which these …