Top 10 challenges in cancer immunotherapy
Cancer immunotherapy is a validated and critically important approach for treating patients
with cancer. Given the vast research and clinical investigation efforts dedicated to advancing …
with cancer. Given the vast research and clinical investigation efforts dedicated to advancing …
Nanocarriers based on bacterial membrane materials for cancer vaccine delivery
Here we present a protocol for the construction and use of two types of nanocarrier based on
bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor …
bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor …
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria
W Wang, H Xu, Q Ye, F Tao, I Wheeldon… - Nature biomedical …, 2022 - nature.com
Because the tumour microenvironment is typically immunosuppressive, the release of
tumour antigens mediated by radiotherapy or chemotherapy does not sufficiently activate …
tumour antigens mediated by radiotherapy or chemotherapy does not sufficiently activate …
Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
The cellular and molecular mechanisms underlying tumor cell PD-L1 (tPD-L1) function in
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …
Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma
L Haas, A Elewaut, CL Gerard, C Umkehrer… - Nature cancer, 2021 - nature.com
How targeted therapies and immunotherapies shape tumors, and thereby influence
subsequent therapeutic responses, is poorly understood. In the present study, we show, in …
subsequent therapeutic responses, is poorly understood. In the present study, we show, in …
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation
During tumorigenesis, tumors must evolve to evade the immune system and do so by
disrupting the genes involved in antigen processing and presentation or up-regulating …
disrupting the genes involved in antigen processing and presentation or up-regulating …
Noncoding regions are the main source of targetable tumor-specific antigens
CM Laumont, K Vincent, L Hesnard… - Science translational …, 2018 - science.org
Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few
have been identified thus far. We therefore developed a proteogenomic approach to enable …
have been identified thus far. We therefore developed a proteogenomic approach to enable …
Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth
Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer
initiation and foster tumour progression. Cancers deficient in MMR frequently show …
initiation and foster tumour progression. Cancers deficient in MMR frequently show …
[HTML][HTML] Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Summary Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how
their immune-suppressive function is regulated in the tumor microenvironment (TME) …
their immune-suppressive function is regulated in the tumor microenvironment (TME) …
[HTML][HTML] Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo
M Hashemzaei, A Delarami Far… - Oncology …, 2017 - … .spandidos-publications.com
The present study focused on the elucidation of the putative anticancer potential of
quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in …
quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in …