In many areas of the vertebrate brain, such as the cerebral and cerebellar cortices, neural
circuits rely on inhibition mediated by GABA (γ-aminobutyric acid) to shape the …

Interneurons are GABAergic neurons responsible for inhibitory activity in the adult
hippocampus, thereby controlling the activity of principal excitatory cells through the …

Processing of neural information is thought to occur by integration of excitatory and inhibitory
synaptic inputs. As such, precise control mechanisms must exist to maintain an appropriate …

Introduction to the synapse 2.1. Development of NMJ 2.2. Development of CNS synapses 3.
Role of adhesion molecules in excitatory synapse development 3.1. Target Recognition and …

The neural cell adhesion molecule (NCAM) regulates synapse formation and synaptic
strength via mechanisms that have remained unknown. We show that NCAM associates with …

Deposition of amyloid-β (Aβ) in the brain is one of the important histopathological features of
Alzheimer's disease (AD). Previously, we reported a correlation between cell adhesion …

Synapses are asymmetric intercellular junctions that mediate neuronal communication. The
number, type, and connectivity patterns of synapses determine the formation, maintenance …

Hundreds of L1CAM gene mutations have been shown to be associated with congenital
hydrocephalus, severe intellectual disability, aphasia, and motor symptoms. How such …

Mammalian brain circuits are wired by dynamic formation and remodeling during
development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation …

Synaptic scaffolding molecule (S‐SCAM) is a synaptic protein, which harbors five or six PSD‐
95/Discs large/ZO‐1 (PDZ), a guanylate kinase and two WW domains. It interacts with NMDA …